+30 69 51 68 16 26    info@crossbees.com

Pre-implantation diagnosis

In the case of genetic mutations, a quite promising method exists to avoid passing it to the offspring: the pre-implantation genetic diagnosis. Although a PID cannot guarantee a successful pregnancy or healthy offspring, couples with genetic diseases are advised to take this method into account. These couples should first consult a geneticist, who will work in close association with reproductive medicine. The laboratory prepares the “haplotype”, something like a genetic fingerprint of the family. It is, therefore, often important to get more DNA samples from family members concerned.

Later, a biopsy of the embryos that are available from IVF follows. A cell from a 6–8 cell stage embryo is retrieved (which corresponds to about three days after fertilization), and subsequently, embryos affected by the disease are excluded from the transfer. 

 Beispiel der Vererbung einer autosomal rezessiven Erkrankung

Pre-implantation genetic screening (PGS)

Pre-implantation genetic screening (PGS) is a broader, quite promising method for old couples and couples with repeated miscarriages or other unsuccessful attempts. We briefly explain the principles of this method.

During conception, 23 female and 23 male chromosomes meet each other and create a healthy 46-chromosome embryo. The division of chromosomes is called meiosis and gets more difficult to achieve as age advances. This explains why younger women are more fertile than older women and clarifies the reasons of higher risk for genetic disorders, like Down syndrome, in older pregnant women. Chromosome abnormalities are mainly naturally selected and do not survive conception or implantation, or they end with a miscarriage.

Defects, such as trisomies, monosomies or other combinations, may occur in any chromosome. These defects are called “aneuploidies”.

Screening provides information on the number of such chromosomes. For this reason, a cell is extracted from a 3-day embryo, and embryos with chromosome abnormalities are excluded from transfer. Despite some reservations, e.g., the fact that in some cases defects cannot be detected or defects are erroneously detected on healthy babies, the aneuploide screening is a successful method.

There are two current methods of aneuploide screening:

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CROSSBEES™ offers healthcare consultancy services to those seeking treatment and to clinics offering it and in this website, we have put together some basics around infertility and the legislative environment around Europe.

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We aim to contribute both to Infertility Treatment and Fertility Planning and to make a difference for future generations by providing education and disseminating information.

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48 Themistokli Dervi Avenue 
Athienitis Centennial Building
1066 Nicosia, Cyprus
Tel. +30 69 51 68 16 26
Email: info@crossbees.com
Skype ID : CROSSBEES

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